I have four little ones and I work from home. I know exactly how you feel. The house gets cluttered all the time. I did a sort and declutter. Well, I'm still in the process, but it's getting better. Take one area or room at a time. Declutter and either throw away or donate what you don't really need. Once you get started, it feels so liberating to get rid of stuff.

The process will take several weeks, if you have a large home or a lot of stuff. Once the place is decluttered, keeping it neat is much easier.