Originally Posted by chana613
Did anyone experience significant weight gain while on Zoloft?
Antidepressants, as well as antipsychotics (which may be used to treat anxiety and depression) are renowned for causing weight gain. Many doctors may deny that these drugs cause weight increase, arguing that the decrease in depression/anxiety results in increased eating. While the latter may be partially true, it doesn't explain the often huge weight gain that can accompany antidepressants use. Often the level of weight gain exceeds that of any weight gain the person has previously experienced simply die to overeating.
Luckily not all antidepressants have the same effect on all people; it may be necessary to change medication if weight gain becomes a secondary reason for depression. On the other hand, often side effects (such as weight gain) indicate that the drug is having a positive effect on the sufferer. It's a tough issue...hopefully further drug research will increasing produce "cleaner" drugs with lesser side effects.